Omid A. Khorram, MD, PhD
Title Professor
Institution Charles R. Drew University of Medicine and Science
Department Internal Medicine
School College of Medicine
Address 1731 E. 120th Street


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Education & Training
Teaching
NIH Awarded Grants
Publications
1. Chuang TD, Rehan A, Khorram O. Tranilast induces MiR-200c expression through blockade of RelA/p65 activity in leiomyoma smooth muscle cells. Fertil Steril. 2020 Jun; 113(6):1308-1318.
  View in: PubMed
 
2. Chuang TD, Khorram O. Cross-talk between miR-29c and transforming growth factor-ß3 is mediated by an epigenetic mechanism in leiomyoma. Fertil Steril. 2019 12; 112(6):1180-1189.
  View in: PubMed
 
3. Chuang TD, Sakurai R, Gong M, Khorram O, Rehan VK. Role of miR-29 in mediating offspring lung phenotype in a rodent model of intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2018 11 01; 315(5):R1017-R1026.
  View in: PubMed
 
4. Chuang TD, Xie Y, Yan W, Khorram O. Next-generation sequencing reveals differentially expressed small noncoding RNAs in uterine leiomyoma. Fertil Steril. 2018 05; 109(5):919-929.
  View in: PubMed
 
5. Chuang TD, Khorram O. Regulation of Cell Cycle Regulatory Proteins by MicroRNAs in Uterine Leiomyoma. Reprod Sci. 2019 02; 26(2):250-258.
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6. Chuang TD, Khorram O. Glucocorticoids regulate MiR-29c levels in vascular smooth muscle cells through transcriptional and epigenetic mechanisms. Life Sci. 2017 Oct 01; 186:87-91.
  View in: PubMed
 
7. Chuang TD, Khorram O. Expression Profiling of lncRNAs, miRNAs, and mRNAs and Their Differential Expression in Leiomyoma Using Next-Generation RNA Sequencing. Reprod Sci. 2018 02; 25(2):246-255.
  View in: PubMed
 
8. Chuang TD, Khorram O. Tranilast Inhibits Genes Functionally Involved in Cell Proliferation, Fibrosis, and Epigenetic Regulation and Epigenetically Induces miR-29c Expression in Leiomyoma Cells. Reprod Sci. 2017 09; 24(9):1253-1263.
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9. Chuang TD, Khorram O. Mechanisms underlying aberrant expression of miR-29c in uterine leiomyoma. Fertil Steril. 2016 Jan; 105(1):236-45.e1.
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10. Chuang TD, Pearce WJ, Khorram O. miR-29c induction contributes to downregulation of vascular extracellular matrix proteins by glucocorticoids. Am J Physiol Cell Physiol. 2015 Jul 15; 309(2):C117-25.
  View in: PubMed
 
11. Khorram O, Keen-Rinehart E, Chuang TD, Ross MG, Desai M. Maternal undernutrition induces premature reproductive senescence in adult female rat offspring. Fertil Steril. 2015 Jan; 103(1):291-8.e2.
  View in: PubMed
 
12. Chuang TD, Ho M, Khorram O. The regulatory function of miR-200c on inflammatory and cell-cycle associated genes in SK-LMS-1, a leiomyosarcoma cell line. Reprod Sci. 2015 May; 22(5):563-71.
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13. Paek DS, Sakurai R, Saraswat A, Li Y, Khorram O, Torday JS, Rehan VK. Metyrapone alleviates deleterious effects of maternal food restriction on lung development and growth of rat offspring. Reprod Sci. 2015 Feb; 22(2):207-22.
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14. Huang G, Basaria S, Travison TG, Ho MH, Davda M, Mazer NA, Miciek R, Knapp PE, Zhang A, Collins L, Ursino M, Appleman E, Dzekov C, Stroh H, Ouellette M, Rundell T, Baby M, Bhatia NN, Khorram O, Friedman T, Storer TW, Bhasin S. Testosterone dose-response relationships in hysterectomized women with or without oophorectomy: effects on sexual function, body composition, muscle performance and physical function in a randomized trial. Menopause. 2014 Jun; 21(6):612-23.
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15. Chuang TD, Khorram O. miR-200c regulates IL8 expression by targeting IKBKB: a potential mediator of inflammation in leiomyoma pathogenesis. PLoS One. 2014; 9(4):e95370.
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16. Durrant LM, Khorram O, Buchholz JN, Pearce WJ. Maternal food restriction modulates cerebrovascular structure and contractility in adult rat offspring: effects of metyrapone. Am J Physiol Regul Integr Comp Physiol. 2014 Mar 15; 306(6):R401-10.
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17. Khorram O, Ghazi R, Chuang TD, Han G, Naghi J, Ni Y, Pearce WJ. Excess maternal glucocorticoids in response to in utero undernutrition inhibit offspring angiogenesis. Reprod Sci. 2014 May; 21(5):601-11.
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18. Rehan VK, Li Y, Corral J, Saraswat A, Husain S, Dhar A, Sakurai R, Khorram O, Torday JS. Metyrapone blocks maternal food restriction-induced changes in female rat offspring lung development. Reprod Sci. 2014 Apr; 21(4):517-25.
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19. Pearce WJ, Khorram O. Maturation and differentiation of the fetal vasculature. Clin Obstet Gynecol. 2013 Sep; 56(3):537-48.
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20. Hubbell MC, Semotiuk AJ, Thorpe RB, Adeoye OO, Butler SM, Williams JM, Khorram O, Pearce WJ. Chronic hypoxia and VEGF differentially modulate abundance and organization of myosin heavy chain isoforms in fetal and adult ovine arteries. Am J Physiol Cell Physiol. 2012 Nov 15; 303(10):C1090-103.
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21. Najafi T, Novin MG, Ghazi R, Khorram O. Altered endometrial expression of endothelial nitric oxide synthase in women with unexplained recurrent miscarriage and infertility. Reprod Biomed Online. 2012 Oct; 25(4):408-14.
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22. Butler SM, Abrassart JM, Hubbell MC, Adeoye O, Semotiuk A, Williams JM, Mata-Greenwood E, Khorram O, Pearce WJ. Contributions of VEGF to age-dependent transmural gradients in contractile protein expression in ovine carotid arteries. Am J Physiol Cell Physiol. 2011 Sep; 301(3):C653-66.
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23. Khorram NM, Magee TR, Wang C, Desai M, Ross M, Khorram O. Maternal undernutrition programs offspring adrenal expression of steroidogenic enzymes. Reprod Sci. 2011 Oct; 18(10):931-40.
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24. Khorram O, Han G, Magee T. Cigarette smoke inhibits endometrial epithelial cell proliferation through a nitric oxide-mediated pathway. Fertil Steril. 2010 Jan; 93(1):257-63.
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25. Khorram O, Han G. Influence of progesterone on endometrial nitric oxide synthase expression. Fertil Steril. 2009 May; 91(5 Suppl):2157-62.
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26. Magee TR, Han G, Cherian B, Khorram O, Ross MG, Desai M. Down-regulation of transcription factor peroxisome proliferator-activated receptor in programmed hepatic lipid dysregulation and inflammation in intrauterine growth-restricted offspring. Am J Obstet Gynecol. 2008 Sep; 199(3):271.e1-5.
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27. Khorram O, Khorram N, Momeni M, Han G, Halem J, Desai M, Ross MG. Maternal undernutrition inhibits angiogenesis in the offspring: a potential mechanism of programmed hypertension. Am J Physiol Regul Integr Comp Physiol. 2007 Aug; 293(2):R745-53.
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28. Khorram O, Momeni M, Ferrini M, Desai M, Ross MG. In utero undernutrition in rats induces increased vascular smooth muscle content in the offspring. Am J Obstet Gynecol. 2007 May; 196(5):486.e1-8.
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29. Ross MG, Desai M, Khorram O, McKnight RA, Lane RH, Torday J. Gestational programming of offspring obesity: a potential contributor to Alzheimer's disease. Curr Alzheimer Res. 2007 Apr; 4(2):213-7.
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30. Khorram O, Momeni M, Desai M, Ross MG. Nutrient restriction in utero induces remodeling of the vascular extracellular matrix in rat offspring. Reprod Sci. 2007 Jan; 14(1):73-80.
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31. Salameh W, Helliwell JP, Han G, McPhaul L, Khorram O. Expression of endometrial glycogen synthase kinase-3beta protein throughout the menstrual cycle and its regulation by progesterone. Mol Hum Reprod. 2006 Sep; 12(9):543-9.
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32. Khorram O, Helliwell JP, Katz S, Bonpane CM, Jaramillo L. Two weeks of metformin improves clomiphene citrate-induced ovulation and metabolic profiles in women with polycystic ovary syndrome. Fertil Steril. 2006 May; 85(5):1448-51.
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33. Huang I, Jones J, Khorram O. Human seminal plasma nitric oxide: correlation with sperm morphology and testosterone. Med Sci Monit. 2006 Mar; 12(3):CR103-6.
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34. Han G, Magee T, Khorram O. Regulation of nitric oxide synthase isoforms by estrogen in the human endometrium. Fertil Steril. 2005 Oct; 84 Suppl 2:1220-7.
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35. Schwimmer JB, Khorram O, Chiu V, Schwimmer WB. Abnormal aminotransferase activity in women with polycystic ovary syndrome. Fertil Steril. 2005 Feb; 83(2):494-7.
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36. Ho MH, Bhatia NN, Khorram O. Physiologic role of nitric oxide and nitric oxide synthase in female lower urinary tract. Curr Opin Obstet Gynecol. 2004 Oct; 16(5):423-9.
  View in: PubMed
 
37. Khorram O, Garthwaite M, Jones J, Golos T. Expression of aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) mRNA expression in human spermatozoa. Med Sci Monit. 2004 May; 10(5):BR135-8.
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38. Katz S, Marshall J, Khorram O. An unusual case of ovarian resistance syndrome. Obstet Gynecol. 2003 May; 101(5 Pt 2):1078-82.
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39. Khorram O, Colman RJ, Kemnitz JW, Magness RR, Zhang J, Yao Z, Keller ET. The influence of sex hormones on circulating nitric oxide (NOx) levels in rhesus monkeys (Macaca Mulatta). Med Sci Monit. 2002 Dec; 8(12):BR489-95.
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40. Khorram O, Lessey BA. Alterations in expression of endometrial endothelial nitric oxide synthase and alpha(v)beta(3) integrin in women with endometriosis. Fertil Steril. 2002 Oct; 78(4):860-4.
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41. Ross MG, Khorram O. Recalculation of gestational sac losses in multifetal pregnancy. Am J Obstet Gynecol. 2002 Sep; 187(3):820-1; author reply 821.
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42. Khorram O. Nitric oxide and its role in blastocyst implantation. Rev Endocr Metab Disord. 2002 May; 3(2):145-9.
  View in: PubMed
 
Funding Opportunities

Click terms below for current NIH/NSF funding opportunities.
  • MicroRNAs


  • Leiomyoma


  • Uterine Neoplasms


  • Epigenesis, Genetic


  • Muscle, Smooth, Vascular


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Keywords   
MicroRNAs
Leiomyoma
Uterine Neoplasms
Epigenesis, Genetic
Muscle, Smooth, Vascular
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Co-Authors  
Ferrini, Monica
Friedman, Theodore
Ho, Matthew
Magee, Thomas
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Physical Neighbors  
Sinha-Hikim, Indrani
Trinh, Khanhphong
Ho, Matthew
Singh, Rajan
Sinha, Satyesh


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