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Rajan Singh, PhD

InstitutionCharles R. Drew University of Medicine and Science
DepartmentInternal Medicine
Address1731 E. 120th Street
Los Angeles CA 90059
Phone(323) 563-5828
FaxNot Available
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    Jadavpur University, IndiaPhD1993Molecular Biology/Microbiology
    Kolkata University, IndiaM.Sc.1986Biochemistry
    Kolkata University, IndiaB.Sc.1984Chemistry (Hons), Math, Physics, English
    2003 - 2007MBRS SCORE, NIH/NIGMS
    2003Outsatnding Young Investigator Award, American Federation of Medical Research
    2004GlaxoSmith Cline Scholar Award, American Federation of Medical Research
    2004 - 2008R01DK070534, National Institute on Aging (Co-Investigator)
    2006Endocrine Society Travel Award, Endocrine Society, USA
    2008RCMI Travel Award, 11th RCMI International Symposium
    2008 - 2014SC1AG033407, National Institute on Aging (Principal Investigator)
    2009Emerging Scientist Award, LSI, Charles R. Drew University
    2009 - 2011SC1AG033407-ARRA Suppl, National Institute on Aging (Principal Investigator)
    2010WSCI Travel Award, Western Society of Clinical Investigation
    2014 - 20199SC1AG049682, National Institute on Aging (Principal Investigator)

    I have long standing interest and research experience in specific areas of androgen biology and aging research. For last 16 years of my independent career, I have been interested in delineating the molecular mechanism of androgen action on muscle and fat mass. My initial research work led to the identification of follistatin (Fst) as a novel target of androgen action via activation of Wnt/ß-catenin signaling pathway, and subsequent identification of anabolic pathways that are differentially responsive to testosterone in muscle and prostate tissues.
    Using a systematic and comprehensive genetic approach, we identified a novel role of Fst in controlling brown adipose characteristics. My research laboratory demonstrated that Fst over-expression both in-vitro and in-vivo favorably alters lipidomic/metabolomic profiles implicated in lipoprotein and energy metabolism. This work is the first to demonstrate the action of Fst in targeting both browning of white adipose tissue (WAT) and activation of classical brown adipose tissue (BAT) through distinct molecular mechanisms and have tremendous therapeutic potential of Fst for the treatment of obesity and related metabolic syndromes. These novel information regarding potential beneficial effects of Fst has been awarded US patent (US9682093B2) entitled “Composition and Methods for Treating or Preventing Metabolic Syndrome Disorders”. In collaboration with UCLA investigators, we have recently identified a critical role for Fst-induced browning during its antiatherogenic action. Currently, we are investigating the pro-browning and anti-atherogenic role of Fst in details and identifying key molecular targets involved in mitigating dyslipidemia and the development of atherosclerosis using several gain-of-function (adipose-specific Fst transgenic mouse models generated in our laboratory) and loss-of function using Fst-floxed (Fst fl/fl) mouse models. Over the years, my research has been supported by several NIH grants.

    SC1AG049682     (SINGH, RAJAN)Aug 1, 2014 - May 31, 2019
    Follistatin promotes browning and influences energy metabolism
    Role: Principal Investigator

    SC1AG033407     (SINGH, RAJAN)Aug 1, 2008 - Jul 31, 2014
    Role of Follistatin during Androgen Regulation of Body Composition
    Role: Principal Investigator

    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Jimenez T, Friedman T, Vadgama J, Singh V, Tucker A, Collazo J, Sinha S, Hikim AS, Singh R, Pervin S. Nicotine Synergizes with High-Fat Diet to Induce an Anti-Inflammatory Microenvironment to Promote Breast Tumor Growth. Mediators Inflamm. 2020; 2020:5239419. PMID: 33414685; PMCID: PMC7752272.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    2. Jimenez T, Barrios A, Tucker A, Collazo J, Arias N, Fazel S, Baker M, Halim M, Huynh T, Singh R, Pervin S. DUSP9-mediated reduction of pERK1/2 supports cancer stem cell-like traits and promotes triple negative breast cancer. Am J Cancer Res. 2020; 10(10):3487-3506. PMID: 33163285; PMCID: PMC7642669.
      Citations: 7     
    3. Singh R, Braga M, Reddy ST, Lee SJ, Parveen M, Grijalva V, Vergnes L, Pervin S. Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues. Endocrinology. 2017 05 01; 158(5):1217-1230. PMID: 28324027; PMCID: PMC5460830.
      Citations: 24     Fields:    Translation:AnimalsCells
    4. Singh R, Parveen M, Basgen JM, Fazel S, Meshesha MF, Thames EC, Moore B, Martinez L, Howard CB, Vergnes L, Reue K, Pervin S. Increased Expression of Beige/Brown Adipose Markers from Host and Breast Cancer Cells Influence Xenograft Formation in Mice. Mol Cancer Res. 2016 Jan; 14(1):78-92. PMID: 26464213; PMCID: PMC4749269.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    5. Singh R, Braga M, Pervin S. Regulation of brown adipocyte metabolism by myostatin/follistatin signaling. Front Cell Dev Biol. 2014; 2:60. PMID: 25364764; PMCID: PMC4207030.
      Citations: 32     
    6. Braga M, Reddy ST, Vergnes L, Pervin S, Grijalva V, Stout D, David J, Li X, Tomasian V, Reid CB, Norris KC, Devaskar SU, Reue K, Singh R. Follistatin promotes adipocyte differentiation, browning, and energy metabolism. J Lipid Res. 2014 Mar; 55(3):375-84. PMID: 24443561; PMCID: PMC3934723.
      Citations: 49     Fields:    Translation:AnimalsCells
    7. Braga M, Pervin S, Norris K, Bhasin S, Singh R. Inhibition of in vitro and in vivo brown fat differentiation program by myostatin. Obesity (Silver Spring). 2013 Jun; 21(6):1180-8. PMID: 23868854; PMCID: PMC3735638.
      Citations: 27     Fields:    Translation:AnimalsCells
    8. Pervin S, Hewison M, Braga M, Tran L, Chun R, Karam A, Chaudhuri G, Norris K, Singh R. Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapy. PLoS One. 2013; 8(1):e53287. PMID: 23341935; PMCID: PMC3544824.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    9. Braga M, Bhasin S, Jasuja R, Pervin S, Singh R. Testosterone inhibits transforming growth factor-ß signaling during myogenic differentiation and proliferation of mouse satellite cells: potential role of follistatin in mediating testosterone action. Mol Cell Endocrinol. 2012 Mar 05; 350(1):39-52. PMID: 22138414; PMCID: PMC3264813.
      Citations: 34     Fields:    Translation:AnimalsCells
    10. Pervin S, Chaudhuri G, Singh R. NO to breast: when, why and why not? Curr Pharm Des. 2010; 16(4):451-62. PMID: 20236074; PMCID: PMC4417623.
      Citations: 6     Fields:    Translation:HumansAnimals
    11. Artaza JN, Singh R, Ferrini MG, Braga M, Tsao J, Gonzalez-Cadavid NF. Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts. J Endocrinol. 2008 Feb; 196(2):235-49. PMID: 18252947.
      Citations: 27     Fields:    Translation:AnimalsCells
    12. Jasuja R, Ramaraj P, Mac RP, Singh AB, Storer TW, Artaza J, Miller A, Singh R, Taylor WE, Lee ML, Davidson T, Sinha-Hikim I, Gonzalez-Cadavid N, Bhasin S. Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men. J Clin Endocrinol Metab. 2005 Feb; 90(2):855-63. PMID: 15522925.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    13. Bhasin S, Taylor WE, Singh R, Artaza J, Sinha-Hikim I, Jasuja R, Choi H, Gonzalez-Cadavid NF. The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action. J Gerontol A Biol Sci Med Sci. 2003 Dec; 58(12):M1103-10. PMID: 14684707.
      Citations: 55     Fields:    Translation:HumansCells
    14. Singh R, Artaza JN, Taylor WE, Gonzalez-Cadavid NF, Bhasin S. Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway. Endocrinology. 2003 Nov; 144(11):5081-8. PMID: 12960001.
      Citations: 159     Fields:    Translation:AnimalsCells
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