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Theodore Friedman, MD, PhD

InstitutionCharles R. Drew University of Medicine and Science
DepartmentInternal Medicine
Address1731 E. 120th Street
Los Angeles CA 90059
Phone(310) 668-5197
FaxNot Available
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    Dr. Friedman's basic science research interests are in pro-hormone processing as related to drug addiction, diabetes, thyroid disease and obesity as well as substance abuse and the hypothalamic-pituitary-adrenal axis. He also is studying how glucocorticoids and enzymes that regulate their tissue levels are involved in diabetes and obesity. His clinical research interests are adrenal and pituitary disorders and he has an NIH-funded clinical trial giving testosterone to women with hypopituitarism. His clinic interests includes difficult to diagnose pituitary, adrenal and thyroid disorders. He is one of the world's experts on Cushing's syndrome. He also wrote a popular lay book on thyroid diseases.

    R25DA050723     (FRIEDMAN, THEODORE C)Apr 1, 2020 - Mar 31, 2025
    The Next Generation Substance Abuse Research Training at Charles R. Drew University (CDU) and UCLA (NGSART-CU)
    Role: Principal Investigator

    R01MD012579     (NAJJAR, SONIA M.)Mar 12, 2019 - Nov 30, 2023
    Novel pathways in the pathogenesis and pathophysiology of NAFLD in Hispanics
    Role: Co-Principal Investigator

    R21DA022342     (FRIEDMAN, THEODORE C)Sep 30, 2007 - Aug 31, 2010
    The mechanisms of the nicotine-induction of insulin resistance
    Role: Principal Investigator

    R24DA017298     (FRIEDMAN, THEODORE C)Sep 1, 2003 - Mar 31, 2021
    CDU Diversity-promoting Institutions Drug Abuse Research Development Program
    Role: Principal Investigator

    U54HD041748     (FRIEDMAN, THEODORE C)Aug 15, 2003 - Oct 31, 2010
    Role: Principal Investigator

    S06GM068510     (SINHA HIKIM, AMIYA P)Aug 1, 2003 - Aug 31, 2012
    Support of Competitive Research (SCORE) Institutional Development Award at Drew
    Role: Co-Principal Investigator

    R21DA016867     (FRIEDMAN, THEODORE C)Jul 20, 2003 - May 31, 2007
    Chronic Nicotine's Activation of the HPA Axis
    Role: Principal Investigator

    R21DA015466     (FRIEDMAN, THEODORE C)Jun 5, 2003 - Feb 29, 2008
    HPA Axis Activation and Nicotine Use
    Role: Principal Investigator

    R01DA014659     (FRIEDMAN, THEODORE C)Aug 1, 2002 - Jul 31, 2010
    Genes and Proteins Leading to Addiction
    Role: Principal Investigator

    K21DA000276     (FRIEDMAN, THEODORE C)Jul 1, 1995 - Apr 30, 2001
    Role: Principal Investigator

    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hasan KM, Parveen M, Pena A, Bautista F, Rivera JC, Huerta RR, Martinez E, Espinoza-Derout J, Sinha-Hikim AP, Friedman TC. Fatty Acid Excess Dysregulates CARF to Initiate the Development of Hepatic Steatosis. Cells. 2023 04 01; 12(7). PMID: 37048142; PMCID: PMC10093423.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Shaheen M, Schrode KM, Tedlos M, Pan D, Najjar SM, Friedman TC. Racial/ethnic and gender disparity in the severity of NAFLD among people with diabetes or prediabetes. Front Physiol. 2023; 14:1076730. PMID: 36891143; PMCID: PMC9986441.
    3. Espinoza-Derout J, Shao XM, Lao CJ, Hasan KM, Rivera JC, Jordan MC, Echeverria V, Roos KP, Sinha-Hikim AP, Friedman TC. Electronic Cigarette Use and the Risk of Cardiovascular Diseases. Front Cardiovasc Med. 2022; 9:879726. PMID: 35463745; PMCID: PMC9021536.
      Citations: 6     
    4. Kim SC, Friedman TC. A New Ingenious Enemy: Heat-Not-Burn Products. Tob Use Insights. 2022; 15:1179173X221076419. PMID: 35237081; PMCID: PMC8883376.
      Citations: 1     
    5. Baskerville WA, Friedman TC, Hurley B, Hsieh S, Dixon T, Mtume N, Lee ML, Rodriguez L, Lopez B, Ray LA. Embedding comprehensive smoking cessation programs into community clinics: study protocol for a cluster-randomized controlled trial. Trials. 2022 Feb 03; 23(1):109. PMID: 35115017; PMCID: PMC8811740.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    6. Shaheen M, Schrode KM, Pan D, Kermah D, Puri V, Zarrinpar A, Elisha D, Najjar SM, Friedman TC. Sex-Specific Differences in the Association Between Race/Ethnicity and NAFLD Among US Population. Front Med (Lausanne). 2021; 8:795421. PMID: 34926533; PMCID: PMC8674562.
      Citations: 4     
    7. Kim SCJ, Martinez JE, Liu Y, Friedman TC. US Tobacco 21 is Paving the Way for a Tobacco Endgame. Tob Use Insights. 2021; 14:1179173X211050396. PMID: 34866950; PMCID: PMC8637783.
      Citations: 2     
    8. Meredith LR, Baskerville WA, Friedman TC, Hurley B, Dixon T, Mtume N, Rodriguez L, Lopez B, Hsieh S, Ray LA. Safety Net Provider Attitudes Toward Smoking Cessation Treatment. Front Psychiatry. 2021; 12:744816. PMID: 34650457; PMCID: PMC8505698.
    9. Shaheen M, Pan D, Schrode KM, Kermah D, Puri V, Zarrinpar A, Elisha D, Najjar SM, Friedman TC. Reassessment of the Hispanic Disparity: Hepatic Steatosis Is More Prevalent in Mexican Americans Than Other Hispanics. Hepatol Commun. 2021 12; 5(12):2068-2079. PMID: 34558824; PMCID: PMC8631095.
      Citations: 5     Fields:    Translation:Humans
    10. Martinez-Hollingsworth A, Kim L, Richardson TG, Angulo M, Liu R, Friedman T, Choi K. Supporting "Bleeders" and "Billers": How Safety-Net Administrators Mitigate Provider Burnout During the COVID-19 Pandemic and Beyond. J Ambul Care Manage. 2021 Jul-Sep 01; 44(3):172-183. PMID: 34016846; PMCID: PMC8174579.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    11. Martinez JE, Kahana DD, Ghuman S, Wilson HP, Wilson J, Kim SCJ, Lagishetty V, Jacobs JP, Sinha-Hikim AP, Friedman TC. Unhealthy Lifestyle and Gut Dysbiosis: A Better Understanding of the Effects of Poor Diet and Nicotine on the Intestinal Microbiome. Front Endocrinol (Lausanne). 2021; 12:667066. PMID: 34168615; PMCID: PMC8218903.
      Citations: 20     Fields:    Translation:Humans
    12. Saldivar P, Mira V, Duran P, Moldovan C, Ang G, Parikh N, Lee ML, Friedman TC. Implementing texting programs in the P.O.W.E.R. (preventing obesity with eating right) medical group visit for weight loss. Obes Sci Pract. 2021 Oct; 7(5):583-590. PMID: 34631136; PMCID: PMC8488446.
    13. Wang Y, Wang J, Yang R, Wang P, Porche R, Kim S, Lutfy K, Liu L, Friedman TC, Jiang M, Liu Y. Decreased 11ß-Hydroxysteroid Dehydrogenase Type 2 Expression in the Kidney May Contribute to Nicotine/Smoking-Induced Blood Pressure Elevation in Mice. Hypertension. 2021 06; 77(6):1940-1952. PMID: 33813843; PMCID: PMC8119334.
      Citations: 2     Fields:    Translation:AnimalsCells
    14. Nguyen S, Mangubat M, Eleswarapu S, Wilson JB, Molina J, Abraham A, Artaza JN, Friedman TC, Ferrini MG. The Combination of High-Fat Diet and Oral Marijuana Promotes the Development of Fibrosis in the Mouse Corpora Cavernosa. Sex Med. 2021 Apr; 9(2):100312. PMID: 33540365; PMCID: PMC8072182.
      Citations: 2     
    15. Hsia SH, Nisis ML, Lee ML, Goldstein C, Friedman TC. Metabolic parameters in smokers undergoing smoking reduction. J Clin Transl Endocrinol. 2021 Mar; 23:100249. PMID: 33717989; PMCID: PMC7933731.
    16. Taskin OC, Pehlivanoglu B, Reid MD, Friedman T, Lee M, Tadros TS, Bandyopadhyay S, Akinfolarin J, Armutlu A, Basturk O, Adsay V. Löwenstein-Buschke: Clinicopathologic Analysis of 78 Cases of Large and Giant Condyloma Acuminata of the Anus. Turk Patoloji Derg. 2021; 37(1):18-25. PMID: 33021736.
      Citations:    Fields:    Translation:Humans
    17. Jimenez T, Friedman T, Vadgama J, Singh V, Tucker A, Collazo J, Sinha S, Hikim AS, Singh R, Pervin S. Nicotine Synergizes with High-Fat Diet to Induce an Anti-Inflammatory Microenvironment to Promote Breast Tumor Growth. Mediators Inflamm. 2020; 2020:5239419. PMID: 33414685; PMCID: PMC7752272.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    18. Hasan KM, Munoz A, Tumoyan H, Parveen M, Espinoza-Derout J, Shao XM, Mahata SK, Friedman TC, Sinha-Hikim AP. Adverse effects of fetal exposure of electronic-cigarettes and high-fat diet on male neonatal hearts. Exp Mol Pathol. 2021 02; 118:104573. PMID: 33212125; PMCID: PMC8501912.
      Citations:    Fields:    Translation:AnimalsCells
    19. Wilson JB, Zopey M, Augustine J, Schaffer R, Chiang M, Friedman TC. High Prevalence of Adrenal Remnant Tissue in Patients Undergoing Bilateral Adrenalectomy for Cushing's Disease. Horm Metab Res. 2021 Mar; 53(3):161-168. PMID: 33091942; PMCID: PMC8570053.
      Citations:    Fields:    Translation:Humans
    20. Hasan KM, Friedman TC, Parveen M, Espinoza-Derout J, Bautista F, Razipour MM, Shao XM, Jordan MC, Roos KP, Mahata SK, Sinha-Hikim AP. Electronic cigarettes cause alteration in cardiac structure and function in diet-induced obese mice. PLoS One. 2020; 15(10):e0239671. PMID: 33002059; PMCID: PMC7529198.
      Citations: 6     Fields:    Translation:Animals
    21. Shao XM, Friedman TC. Last Word on Viewpoint: pH Buffer capacity and pharmacokinetics: two remaining questions. J Appl Physiol (1985). 2020 04 01; 128(4):1063-1064. PMID: 32284007; PMCID: PMC7276929.
      Citations: 1     Fields:    
    22. Shao XM, Friedman TC. Pod-mod vs. conventional e-cigarettes: nicotine chemistry, pH, and health effects. J Appl Physiol (1985). 2020 04 01; 128(4):1056-1058. PMID: 31854246; PMCID: PMC7191502.
      Citations: 21     Fields:    
    23. Wang J, Wang Y, Liu L, Lutfy K, Friedman TC, Liu Y, Jiang M, Liu Y. Lack of adipose-specific hexose-6-phosphate dehydrogenase causes inactivation of adipose glucocorticoids and improves metabolic phenotype in mice. Clin Sci (Lond). 2019 11 15; 133(21):2189-2202. PMID: 31696216; PMCID: PMC7493827.
      Citations: 1     Fields:    Translation:Animals
    24. Shao XM, Lopez B, Nathan D, Wilson J, Bankole E, Tumoyan H, Munoz A, Espinoza-Derout J, Hasan KM, Chang S, Du C, Sinha-Hikim AP, Lutfy K, Friedman TC. A mouse model for chronic intermittent electronic cigarette exposure exhibits nicotine pharmacokinetics resembling human vapers. J Neurosci Methods. 2019 10 01; 326:108376. PMID: 31361999; PMCID: PMC6717674.
      Citations: 15     Fields:    Translation:Animals
    25. Espinoza-Derout J, Hasan KM, Shao XM, Jordan MC, Sims C, Lee DL, Sinha S, Simmons Z, Mtume N, Liu Y, Roos KP, Sinha-Hikim AP, Friedman TC. Chronic intermittent electronic cigarette exposure induces cardiac dysfunction and atherosclerosis in apolipoprotein-E knockout mice. Am J Physiol Heart Circ Physiol. 2019 08 01; 317(2):H445-H459. PMID: 31172811; PMCID: PMC6732484.
      Citations: 34     Fields:    Translation:AnimalsCellsPHPublic Health
    26. Espinoza-Derout J, Shao XM, Bankole E, Hasan KM, Mtume N, Liu Y, Sinha-Hikim AP, Friedman TC. Hepatic DNA Damage Induced by Electronic Cigarette Exposure Is Associated With the Modulation of NAD+/PARP1/SIRT1 Axis. Front Endocrinol (Lausanne). 2019; 10:320. PMID: 31214115; PMCID: PMC6558099.
      Citations: 10     Fields:    
    27. Hasan KM, Friedman TC, Shao X, Parveen M, Sims C, Lee DL, Espinoza-Derout J, Sinha-Hikim I, Sinha-Hikim AP. E-cigarettes and Western Diet: Important Metabolic Risk Factors for Hepatic Diseases. Hepatology. 2019 06; 69(6):2442-2454. PMID: 30664268; PMCID: PMC6636679.
      Citations: 16     Fields:    Translation:HumansAnimals
    28. Mojtahedzadeh M, Shaesteh N, Haykani M, Tran JLA, Mangubat M, Shahinian HK, Nachnani R, Zopey M, Saidian J, Thomas A, Lee ML, McCutcheon IE, Friedman TC. Low-Dose and Standard Overnight and Low Dose-Two Day Dexamethasone Suppression Tests in Patients with Mild and/or Episodic Hypercortisolism. Horm Metab Res. 2018 Jun; 50(6):453-461. PMID: 29719879; PMCID: PMC6502760.
      Citations: 1     Fields:    Translation:Humans
    29. Liu L, Wang Y, Wang J, Dong Y, Chang S, Liu X, Lutfy K, Chen H, Friedman TC, Jiang M, Liu Y. Enhanced hexose-6-phosphate dehydrogenase expression in adipose tissue may contribute to diet-induced visceral adiposity. Int J Obes (Lond). 2018 12; 42(12):1999-2011. PMID: 29568102; PMCID: PMC6105561.
      Citations: 4     Fields:    Translation:AnimalsCells
    30. Hasan MK, Friedman TC, Sims C, Lee DL, Espinoza-Derout J, Ume A, Chalfant V, Lee ML, Sinha-Hikim I, Lutfy K, Liu Y, Mahata SK, Sinha-Hikim AP. a7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet-Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling. Endocrinology. 2018 02 01; 159(2):931-944. PMID: 29272360; PMCID: PMC5776480.
      Citations: 12     Fields:    Translation:AnimalsCells
    31. Kermah D, Shaheen M, Pan D, Friedman TC. Association between secondhand smoke and obesity and glucose abnormalities: data from the National Health and Nutrition Examination Survey (NHANES 1999-2010). BMJ Open Diabetes Res Care. 2017; 5(1):e000324. PMID: 28405342; PMCID: PMC5372029.
      Citations: 11     
    32. Sinha-Hikim AP, Sinha-Hikim I, Friedman TC. Connection of Nicotine to Diet-Induced Obesity and Non-Alcoholic Fatty Liver Disease: Cellular and Mechanistic Insights. Front Endocrinol (Lausanne). 2017; 8:23. PMID: 28239368; PMCID: PMC5300964.
      Citations: 18     Fields:    
    33. Sinha-Hikim I, Friedman TC, Falz M, Chalfant V, Hasan MK, Espinoza-Derout J, Lee DL, Sims C, Tran P, Mahata SK, Sinha-Hikim AP. Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. Cell Tissue Res. 2017 04; 368(1):159-170. PMID: 27917437; PMCID: PMC5813800.
      Citations: 12     Fields:    Translation:AnimalsCells
    34. Harris KK, Zopey M, Friedman TC. Metabolic effects of smoking cessation. Nat Rev Endocrinol. 2016 11; 12(11):684. PMID: 27688045.
      Citations: 9     Fields:    
    35. Lutfy K, Parikh D, Lee DL, Liu Y, Ferrini MG, Hamid A, Friedman TC. Prohormone convertase 2 (PC2) null mice have increased mu opioid receptor levels accompanied by altered morphine-induced antinociception, tolerance and dependence. Neuroscience. 2016 08 04; 329:318-25. PMID: 27208618; PMCID: PMC4933571.
      Citations: 2     Fields:    Translation:Animals
    36. Yan C, Yang H, Wang Y, Dong Y, Yu F, Wu Y, Wang W, Adaku U, Lutfy K, Friedman TC, Tian S, Liu Y. Increased glycogen synthase kinase-3ß and hexose-6-phosphate dehydrogenase expression in adipose tissue may contribute to glucocorticoid-induced mouse visceral adiposity. Int J Obes (Lond). 2016 08; 40(8):1233-41. PMID: 27102048; PMCID: PMC4970937.
      Citations: 5     Fields:    Translation:AnimalsCells
    37. Harris KK, Zopey M, Friedman TC. Metabolic effects of smoking cessation. Nat Rev Endocrinol. 2016 May; 12(5):299-308. PMID: 26939981; PMCID: PMC5021526.
      Citations: 52     Fields:    Translation:Humans
    38. Weintraub AY, Friedman T, Baumfeld Y, Neuman M, Krissi H. Long term subjective cure rate, urinary tract symptoms and dyspareunia following mesh augmented anterior vaginal wall prolapse repair. Int J Surg. 2015 Dec; 24(Pt A):33-8. PMID: 26525268.
      Citations:    Fields:    Translation:Humans
    39. Mojtahedzadeh M, Lee ML, Friedman TC. Continuation or discontinuation of pioglitazone when starting bedtime insulin in patients with poorly controlled type 2 diabetes in an inner-city population. J Diabetes Complications. 2015 Nov-Dec; 29(8):1248-52. PMID: 26215435; PMCID: PMC5014540.
      Citations: 1     Fields:    Translation:Humans
    40. Wang Y, Yan C, Liu L, Wang W, Du H, Fan W, Lutfy K, Jiang M, Friedman TC, Liu Y. 11ß-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue. Am J Physiol Endocrinol Metab. 2015 Jan 01; 308(1):E84-95. PMID: 25389364; PMCID: PMC4281684.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    41. Sinha-Hikim I, Duran P, Shen R, Lee M, Friedman TC, Davidson MB. Effect of long term vitamin D supplementation on biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D. Horm Metab Res. 2015 Apr; 47(4):280-3. PMID: 25011019; PMCID: PMC4648252.
      Citations: 16     Fields:    Translation:Humans
    42. Huang G, Basaria S, Travison TG, Ho MH, Davda M, Mazer NA, Miciek R, Knapp PE, Zhang A, Collins L, Ursino M, Appleman E, Dzekov C, Stroh H, Ouellette M, Rundell T, Baby M, Bhatia NN, Khorram O, Friedman T, Storer TW, Bhasin S. Testosterone dose-response relationships in hysterectomized women with or without oophorectomy: effects on sexual function, body composition, muscle performance and physical function in a randomized trial. Menopause. 2014 Jun; 21(6):612-23. PMID: 24281237; PMCID: PMC4701202.
      Citations: 28     Fields:    Translation:Humans
    43. Ivey R, Desai M, Green K, Sinha-Hikim I, Friedman TC, Sinha-Hikim AP. Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling. Horm Metab Res. 2014 Jul; 46(8):568-73. PMID: 24830635; PMCID: PMC4327908.
      Citations: 10     Fields:    Translation:AnimalsCells
    44. Sinha-Hikim I, Friedman TC, Shin CS, Lee D, Ivey R, Sinha-Hikim AP. Nicotine in combination with a high-fat diet causes intramyocellular mitochondrial abnormalities in male mice. Endocrinology. 2014 Mar; 155(3):865-72. PMID: 24424058; PMCID: PMC3929732.
      Citations: 16     Fields:    Translation:AnimalsCells
    45. Wang Y, Liu L, Du H, Nagaoka Y, Fan W, Lutfy K, Friedman TC, Jiang M, Liu Y. Transgenic overexpression of hexose-6-phosphate dehydrogenase in adipose tissue causes local glucocorticoid amplification and lipolysis in male mice. Am J Physiol Endocrinol Metab. 2014 Mar 01; 306(5):E543-51. PMID: 24381005; PMCID: PMC3948972.
      Citations: 6     Fields:    Translation:AnimalsCells
    46. Natividad LA, Torres OV, Friedman TC, O'Dell LE. Adolescence is a period of development characterized by short- and long-term vulnerability to the rewarding effects of nicotine and reduced sensitivity to the anorectic effects of this drug. Behav Brain Res. 2013 Nov 15; 257:275-85. PMID: 24120402; PMCID: PMC3965174.
      Citations: 21     Fields:    Translation:Animals
    47. Liu L, Nagashima K, Yasuda T, Liu Y, Hu HR, He G, Feng B, Zhao M, Zhuang L, Zheng T, Friedman TC, Xiang K. Mutations in KCNJ11 are associated with the development of autosomal dominant, early-onset type 2 diabetes. Diabetologia. 2013 Dec; 56(12):2609-18. PMID: 24018988; PMCID: PMC5333983.
      Citations: 13     Fields:    Translation:Humans
    48. Ren X, Lutfy K, Mangubat M, Ferrini MG, Lee ML, Liu Y, Friedman TC. Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake. J Obes. 2013; 2013:764742. PMID: 24073333; PMCID: PMC3773431.
      Citations: 9     Fields:    Translation:AnimalsCells
    49. Nie Y, Ferrini MG, Liu Y, Anghel A, Paez Espinosa EV, Stuart RC, Lutfy K, Nillni EA, Friedman TC. Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2. Peptides. 2013 Sep; 47:99-109. PMID: 23891651; PMCID: PMC3787842.
      Citations: 1     Fields:    Translation:Animals
    50. O'Dell LE, Natividad LA, Pipkin JA, Roman F, Torres I, Jurado J, Torres OV, Friedman TC, Tenayuca JM, Nazarian A. Enhanced nicotine self-administration and suppressed dopaminergic systems in a rat model of diabetes. Addict Biol. 2014 Nov; 19(6):1006-19. PMID: 23834715; PMCID: PMC3842417.
      Citations: 17     Fields:    Translation:Animals
    51. Du H, Liu L, Wang Y, Nakagawa Y, Lyzlov A, Lutfy K, Friedman TC, Peng X, Liu Y. Specific reduction of G6PT may contribute to downregulation of hepatic 11ß-HSD1 in diabetic mice. J Mol Endocrinol. 2013 Apr; 50(2):167-78. PMID: 23267038; PMCID: PMC3763023.
      Citations: 7     Fields:    Translation:AnimalsCells
    52. Teruya SA, Bazargan-Hejazi S, Mojtahedzadeh M, Doshi M, Russell K, Parker-Kelly D, Friedman TC. A Review of Programs, Components and Outcomes in Biomedical Research Faculty Development. Int J Univ Teach Fac Dev. 2013; 4(4):223-236. PMID: 26120379; PMCID: PMC4479301.
      Citations: 3     
    53. Friedman TC, Sinha-Hikim I, Parveen M, Najjar SM, Liu Y, Mangubat M, Shin CS, Lyzlov A, Ivey R, Shaheen M, French SW, Sinha-Hikim AP. Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice. Endocrinology. 2012 Dec; 153(12):5809-20. PMID: 23093702; PMCID: PMC3512067.
      Citations: 28     Fields:    Translation:AnimalsCells
    54. Davidson MB, Duran P, Lee ML, Friedman TC. High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D. Diabetes Care. 2013 Feb; 36(2):260-6. PMID: 23033239; PMCID: PMC3554269.
      Citations: 87     Fields:    Translation:Humans
    55. Tweed JO, Hsia SH, Lutfy K, Friedman TC. The endocrine effects of nicotine and cigarette smoke. Trends Endocrinol Metab. 2012 Jul; 23(7):334-42. PMID: 22561025; PMCID: PMC3389568.
      Citations: 67     Fields:    Translation:HumansAnimals
    56. Nguyen AT, Marquez P, Hamid A, Kieffer B, Friedman TC, Lutfy K. The rewarding action of acute cocaine is reduced in ß-endorphin deficient but not in µ opioid receptor knockout mice. Eur J Pharmacol. 2012 Jul 05; 686(1-3):50-4. PMID: 22575525; PMCID: PMC3367137.
      Citations: 15     Fields:    Translation:Animals
    57. Rajavashisth TB, Shaheen M, Norris KC, Pan D, Sinha SK, Ortega J, Friedman TC. Decreased prevalence of diabetes in marijuana users: cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III. BMJ Open. 2012; 2:e000494. PMID: 22368296; PMCID: PMC3289985.
      Citations: 52     Fields:    
    58. Lutfy K, Aimiuwu O, Mangubat M, Shin CS, Nerio N, Gomez R, Liu Y, Friedman TC. Nicotine stimulates secretion of corticosterone via both CRH and AVP receptors. J Neurochem. 2012 Mar; 120(6):1108-16. PMID: 22191943; PMCID: PMC3296864.
      Citations: 15     Fields:    Translation:Animals
    59. Mangubat M, Lutfy K, Lee ML, Pulido L, Stout D, Davis R, Shin CS, Shahbazian M, Seasholtz S, Sinha-Hikim A, Sinha-Hikim I, O'Dell LE, Lyzlov A, Liu Y, Friedman TC. Effect of nicotine on body composition in mice. J Endocrinol. 2012 Mar; 212(3):317-26. PMID: 22138237; PMCID: PMC3444240.
      Citations: 29     Fields:    Translation:Animals
    60. Friedman TC. Vitamin D supplementation to prevent the progression of prediabetes to diabetes: getting closer to a recommendation. Transl Res. 2011 Nov; 158(5):273-5. PMID: 22005266; PMCID: PMC3918469.
      Citations: 3     Fields:    Translation:Humans
    61. Wang Y, Nakagawa Y, Liu L, Wang W, Ren X, Anghel A, Lutfy K, Friedman TC, Liu Y. Tissue-specific dysregulation of hexose-6-phosphate dehydrogenase and glucose-6-phosphate transporter production in db/db mice as a model of type 2 diabetes. Diabetologia. 2011 Feb; 54(2):440-50. PMID: 21052977; PMCID: PMC3795617.
      Citations: 18     Fields:    Translation:AnimalsCells
    62. Parikh D, Hamid A, Friedman TC, Nguyen K, Tseng A, Marquez P, Lutfy K. Stress-induced analgesia and endogenous opioid peptides: the importance of stress duration. Eur J Pharmacol. 2011 Jan 15; 650(2-3):563-7. PMID: 21044625; PMCID: PMC3033575.
      Citations: 31     Fields:    Translation:AnimalsCells
    63. Friedman TC, Ghods DE, Shahinian HK, Zachery L, Shayesteh N, Seasholtz S, Zuckerbraun E, Lee ML, McCutcheon IE. High prevalence of normal tests assessing hypercortisolism in subjects with mild and episodic Cushing's syndrome suggests that the paradigm for diagnosis and exclusion of Cushing's syndrome requires multiple testing. Horm Metab Res. 2010 Nov; 42(12):874-81. PMID: 20803415; PMCID: PMC2978784.
      Citations: 11     Fields:    Translation:Humans
    64. Kilimnik G, Kim A, Steiner DF, Friedman TC, Hara M. Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic a-cells in mouse models of ß-cell regeneration. Islets. 2010 May-Jun; 2(3):149-55. PMID: 20657753; PMCID: PMC2908328.
      Citations: 60     Fields:    Translation:AnimalsCells
    65. Anghel A, Jamieson CA, Ren X, Young J, Porche R, Ozigbo E, Ghods DE, Lee ML, Liu Y, Lutfy K, Friedman TC. Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake. Neuroscience. 2010 May 05; 167(2):554-66. PMID: 20144693; PMCID: PMC2859888.
      Citations: 9     Fields:    Translation:Animals
    66. Chen J, Patel R, Friedman TC, Jones KS. The Behavioral and Pharmacological Actions of NMDA Receptor Antagonism are Conserved in Zebrafish Larvae. Int J Comp Psychol. 2010; 23(1):82-90. PMID: 21278812; PMCID: PMC3027073.
      Citations: 15     
    67. Vuong C, Van Uum SH, O'Dell LE, Lutfy K, Friedman TC. The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev. 2010 Feb; 31(1):98-132. PMID: 19903933; PMCID: PMC2852206.
      Citations: 166     Fields:    Translation:HumansAnimals
    68. Thomson S, Koren G, Fraser LA, Rieder M, Friedman TC, Van Uum SH. Hair analysis provides a historical record of cortisol levels in Cushing's syndrome. Exp Clin Endocrinol Diabetes. 2010 Feb; 118(2):133-8. PMID: 19609841; PMCID: PMC2945912.
      Citations: 53     Fields:    Translation:Humans
    69. Pall ME, Lao MC, Patel SS, Lee ML, Ghods DE, Chandler DW, Friedman TC. Testosterone and bioavailable testosterone help to distinguish between mild Cushing's syndrome and polycystic ovarian syndrome. Horm Metab Res. 2008 Nov; 40(11):813-8. PMID: 18819057; PMCID: PMC2954657.
      Citations: 4     Fields:    Translation:Humans
    70. Espinosa VP, Liu Y, Ferrini M, Anghel A, Nie Y, Tripathi PV, Porche R, Jansen E, Stuart RC, Nillni EA, Lutfy K, Friedman TC. Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addiction. Neuroscience. 2008 Oct 15; 156(3):788-99. PMID: 18771713; PMCID: PMC2596639.
      Citations: 11     Fields:    Translation:AnimalsCells
    71. Liu Y, Nakagawa Y, Wang Y, Liu L, Du H, Wang W, Ren X, Lutfy K, Friedman TC. Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice. J Mol Endocrinol. 2008 Aug; 41(2):53-64. PMID: 18524870; PMCID: PMC2954685.
      Citations: 18     Fields:    Translation:AnimalsCells
    72. Fraser LA, Morrison D, Morley-Forster P, Paul TL, Tokmakejian S, Larry Nicholson R, Bureau Y, Friedman TC, Van Uum SH. Oral opioids for chronic non-cancer pain: higher prevalence of hypogonadism in men than in women. Exp Clin Endocrinol Diabetes. 2009 Jan; 117(1):38-43. PMID: 18523930; PMCID: PMC2953550.
      Citations: 29     Fields:    Translation:Humans
    73. Yuen KC, Cook DM, Sahasranam P, Patel P, Ghods DE, Shahinian HK, Friedman TC. Prevalence of GH and other anterior pituitary hormone deficiencies in adults with nonsecreting pituitary microadenomas and normal serum IGF-1 levels. Clin Endocrinol (Oxf). 2008 Aug; 69(2):292-8. PMID: 18221393; PMCID: PMC2953553.
      Citations: 11     Fields:    Translation:Humans
    74. Sahasranam P, Tran MT, Mohamed H, Friedman TC. Multiglandular parathyroid carcinoma: a case report and brief review. South Med J. 2007 Aug; 100(8):841-4. PMID: 17713315.
      Citations: 7     Fields:    Translation:Humans
    75. Friedman TC, Zuckerbraun E, Lee ML, Kabil MS, Shahinian H. Dynamic pituitary MRI has high sensitivity and specificity for the diagnosis of mild Cushing's syndrome and should be part of the initial workup. Horm Metab Res. 2007 Jun; 39(6):451-6. PMID: 17578763.
      Citations: 12     Fields:    Translation:Humans
    76. Lutfy K, Brown MC, Nerio N, Aimiuwu O, Tran B, Anghel A, Friedman TC. Repeated stress alters the ability of nicotine to activate the hypothalamic-pituitary-adrenal axis. J Neurochem. 2006 Dec; 99(5):1321-7. PMID: 17064351.
      Citations: 19     Fields:    Translation:Animals
    77. Espinosa VP, Ferrini M, Shen X, Lutfy K, Nillni EA, Friedman TC. Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E175-86. PMID: 16926379.
      Citations: 4     Fields:    Translation:AnimalsCells
    78. Liu Y, Yan C, Wang Y, Nakagawa Y, Nerio N, Anghel A, Lutfy K, Friedman TC. Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Endocrinology. 2006 Nov; 147(11):5061-8. PMID: 16873540.
      Citations: 28     Fields:    Translation:AnimalsCells
    79. Friedman TC. An update on the overnight dexamethasone suppression test for the diagnosis of Cushing's syndrome: limitations in patients with mild and/or episodic hypercortisolism. Exp Clin Endocrinol Diabetes. 2006 Jul; 114(7):356-60. PMID: 16915537.
      Citations: 8     Fields:    Translation:Humans
    80. Perello M, Friedman T, Paez-Espinosa V, Shen X, Stuart RC, Nillni EA. Thyroid hormones selectively regulate the posttranslational processing of prothyrotropin-releasing hormone in the paraventricular nucleus of the hypothalamus. Endocrinology. 2006 Jun; 147(6):2705-16. PMID: 16497799.
      Citations: 22     Fields:    Translation:AnimalsCells
    81. Marquez P, Baliram R, Gajawada N, Friedman TC, Lutfy K. Differential involvement of enkephalins in analgesic tolerance, locomotor sensitization, and conditioned place preference induced by morphine. Behav Neurosci. 2006 Feb; 120(1):10-5. PMID: 16492112; PMCID: PMC2268890.
      Citations: 16     Fields:    Translation:Animals
    82. McGirr R, Ejbick CE, Carter DE, Andrews JD, Nie Y, Friedman TC, Dhanvantari S. Glucose dependence of the regulated secretory pathway in alphaTC1-6 cells. Endocrinology. 2005 Oct; 146(10):4514-23. PMID: 15994347.
      Citations: 18     Fields:    Translation:AnimalsCells
    83. Hardiman A, Friedman TC, Grunwald WC, Furuta M, Zhu Z, Steiner DF, Cool DR. Endocrinomic profile of neurointermediate lobe pituitary prohormone processing in PC1/3- and PC2-Null mice using SELDI-TOF mass spectrometry. J Mol Endocrinol. 2005 Jun; 34(3):739-51. PMID: 15956344; PMCID: PMC4422198.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    84. Shen X, Li QL, Brent GA, Friedman TC. Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E236-45. PMID: 15585599.
      Citations: 3     Fields:    Translation:AnimalsCells
    85. Liu Y, Nakagawa Y, Wang Y, Sakurai R, Tripathi PV, Lutfy K, Friedman TC. Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice. Diabetes. 2005 Jan; 54(1):32-40. PMID: 15616008.
      Citations: 38     Fields:    Translation:AnimalsCells
    86. Sanchez VC, Goldstein J, Stuart RC, Hovanesian V, Huo L, Munzberg H, Friedman TC, Bjorbaek C, Nillni EA. Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone. J Clin Invest. 2004 Aug; 114(3):357-69. PMID: 15286802; PMCID: PMC484982.
      Citations: 40     Fields:    Translation:AnimalsCells
    87. Shen X, Li QL, Brent GA, Friedman TC. Thyroid hormone regulation of prohormone convertase 1 (PC1): regional expression in rat brain and in vitro characterization of negative thyroid hormone response elements. J Mol Endocrinol. 2004 Aug; 33(1):21-33. PMID: 15291740.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    88. Wang C, Swerdloff R, Kipnes M, Matsumoto AM, Dobs AS, Cunningham G, Katznelson L, Weber TJ, Friedman TC, Snyder P, Levine HL. New testosterone buccal system (Striant) delivers physiological testosterone levels: pharmacokinetics study in hypogonadal men. J Clin Endocrinol Metab. 2004 Aug; 89(8):3821-9. PMID: 15292312.
      Citations: 21     Fields:    Translation:HumansCTClinical Trials
    89. Friedman TC. Prolactinomas. N Engl J Med. 2004 Mar 04; 350(10):1054-7; author reply 1054-7. PMID: 14999121.
      Citations:    Fields:    Translation:Humans
    90. Friedman TC, Shahinian H. Bilateral cerebral aneurysms impinging on the pituitary. Pituitary. 2004; 7(3):193-194. PMID: 16328569.
      Citations:    Fields:    Translation:Humans
    91. Choi HJ, Cornford M, Wang L, Sun J, Friedman TC. Acute chagas' disease presenting with a suprasellar mass and panhypopituitarism. Pituitary. 2004; 7(2):111-4. PMID: 15761661.
      Citations:    Fields:    Translation:HumansAnimals
    92. Liu Y, Nakagawa Y, Wang Y, Li R, Li X, Ohzeki T, Friedman TC. Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob mice. Diabetes. 2003 Jun; 52(6):1409-16. PMID: 12765951.
      Citations: 20     Fields:    Translation:AnimalsCells
    93. Li QL, Naqvi S, Shen X, Liu YJ, Lindberg I, Friedman TC. Prohormone convertase 2 enzymatic activity and its regulation in neuro-endocrine cells and tissues. Regul Pept. 2003 Feb 28; 110(3):197-205. PMID: 12573800.
      Citations: 5     Fields:    Translation:AnimalsCells
    94. Friedman TC, Norris KC. The role of vitamin D in mild to moderate chronic kidney disease. Trends Endocrinol Metab. 2002 Jul; 13(5):189-94. PMID: 12185664.
      Citations:    Fields:    Translation:HumansAnimals
    95. Padero MC, Bhasin S, Friedman TC. Androgen supplementation in older women: too much hype, not enough data. J Am Geriatr Soc. 2002 Jun; 50(6):1131-40. PMID: 12110078.
      Citations: 6     Fields:    Translation:Humans
    96. Nakashima M, Nie Y, Li QL, Friedman TC. Up-regulation of splenic prohormone convertases PC1 and PC2 in diabetic rats. Regul Pept. 2001 Dec 15; 102(2-3):135-45. PMID: 11730986.
      Citations: 5     Fields:    Translation:AnimalsCells
    97. Padero C, Friedman T, Salehian B. Comment on "Editorial: The role of androgens in women". J Clin Endocrinol Metab. 2001 Oct; 86(10):5091-2. PMID: 11600597.
      Citations:    Fields:    Translation:Humans
    98. Li QL, Jansen E, Brent GA, Friedman TC. Regulation of prohormone convertase 1 (PC1) by thyroid hormone. Am J Physiol Endocrinol Metab. 2001 Jan; 280(1):E160-70. PMID: 11120670.
      Citations: 6     Fields:    Translation:AnimalsCells
    99. García-Borreguero D, Wehr TA, Larrosa O, Granizo JJ, Hardwick D, Chrousos GP, Friedman TC. Glucocorticoid replacement is permissive for rapid eye movement sleep and sleep consolidation in patients with adrenal insufficiency. J Clin Endocrinol Metab. 2000 Nov; 85(11):4201-6. PMID: 11095454.
      Citations: 19     Fields:    Translation:HumansCTClinical Trials
    100. Li QL, Jansen E, Brent GA, Naqvi S, Wilber JF, Friedman TC. Interactions between the prohormone convertase 2 promoter and the thyroid hormone receptor. Endocrinology. 2000 Sep; 141(9):3256-66. PMID: 10965896.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    101. Nawab SS, Miller CS, Dale JK, Greenberg BD, Friedman TC, Chrousos GP, Straus SE, Rosenthal NE. Self-reported sensitivity to chemical exposures in five clinical populations and healthy controls. Psychiatry Res. 2000 Jul 24; 95(1):67-74. PMID: 10904124.
      Citations:    Fields:    Translation:Humans
    102. Nie Y, Nakashima M, Brubaker PL, Li QL, Perfetti R, Jansen E, Zambre Y, Pipeleers D, Friedman TC. Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats. J Clin Invest. 2000 Apr; 105(7):955-65. PMID: 10749575; PMCID: PMC377475.
      Citations: 60     Fields:    Translation:Animals
    103. Li QL, Jansen E, Friedman TC. Regulation of prohormone convertase 1 (PC1) by gp130-related cytokines. Mol Cell Endocrinol. 1999 Dec 20; 158(1-2):143-52. PMID: 10630414.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    104. Friedman T, Smith RN, Colvin RB, Iacomini J. A critical role for human CD4+ T-cells in rejection of porcine islet cell xenografts. Diabetes. 1999 Dec; 48(12):2340-8. PMID: 10580422.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    105. Yanovski JA, Miller KD, Kino T, Friedman TC, Chrousos GP, Tsigos C, Falloon J. Endocrine and metabolic evaluation of human immunodeficiency virus-infected patients with evidence of protease inhibitor-associated lipodystrophy. J Clin Endocrinol Metab. 1999 Jun; 84(6):1925-31. PMID: 10372688.
      Citations: 16     Fields:    Translation:HumansCellsCTClinical Trials
    106. Shimon I, Yan X, Magoffin DA, Friedman TC, Melmed S. Intact leptin receptor is selectively expressed in human fetal pituitary and pituitary adenomas and signals human fetal pituitary growth hormone secretion. J Clin Endocrinol Metab. 1998 Nov; 83(11):4059-64. PMID: 9814492.
      Citations: 15     Fields:    Translation:Humans
    107. Friedman TC, Papanicolaou DA. Comment on high urinary free cortisol excretion in a patient with psychogenic polydipsia. J Clin Endocrinol Metab. 1998 Sep; 83(9):3378-9. PMID: 9745460.
      Citations: 1     Fields:    Translation:Humans
    108. Li QL, Yano H, Ren SG, Li X, Friedman TC, Melmed S. Leukemia inhibitory factor (LIF) modulates pro-opiomelanocortin (POMC) gene regulation in stably transfected AtT-20 cells overexpressing LIF. Endocrine. 1997 Dec; 7(3):325-30. PMID: 9657069.
      Citations: 1     Fields:    Translation:HumansCells
    109. Yanovski JA, Friedman TC, Nieman LK, Chrousos GP, Cutler GB, Doppman JL, Kalogeras KT. Inferior petrosal sinus AVP in patients with Cushing's syndrome. Clin Endocrinol (Oxf). 1997 Aug; 47(2):199-206. PMID: 9302395.
      Citations:    Fields:    Translation:Humans
    110. Taymans SE, DeVries AC, DeVries MB, Nelson RJ, Friedman TC, Castro M, Detera-Wadleigh S, Carter CS, Chrousos GP. The hypothalamic-pituitary-adrenal axis of prairie voles (Microtus ochrogaster): evidence for target tissue glucocorticoid resistance. Gen Comp Endocrinol. 1997 Apr; 106(1):48-61. PMID: 9126465.
      Citations: 26     Fields:    Translation:Animals
    111. Dorn LD, Burgess ES, Friedman TC, Dubbert B, Gold PW, Chrousos GP. The longitudinal course of psychopathology in Cushing's syndrome after correction of hypercortisolism. J Clin Endocrinol Metab. 1997 Mar; 82(3):912-9. PMID: 9062506.
      Citations: 58     Fields:    Translation:Humans
    112. Friedman TC, Mastorakos G, Newman TD, Mullen NM, Horton EG, Costello R, Papadopoulos NM, Chrousos GP. Carbohydrate and lipid metabolism in endogenous hypercortisolism: shared features with metabolic syndrome X and NIDDM. Endocr J. 1996 Dec; 43(6):645-55. PMID: 9075604.
      Citations: 37     Fields:    Translation:Humans
    113. Yanovski JA, Yanovski SZ, Friedman TC, Loh YP, Jayasvasti V, Cutler GB, Chrousos GP. Etiology of the differences in corticotropin-releasing hormone-induced adrenocorticotropin secretion of black and white women. J Clin Endocrinol Metab. 1996 Sep; 81(9):3307-11. PMID: 8784088.
      Citations: 5     Fields:    Translation:Humans
    114. Friedman TC, Yanovski JA, Nieman LK, Doppman JL, Cutler GB, Oldfield EH, Gold PM, Chrousos GP, Kalogeras KT. Inferior petrosal sinus arginine vasopressin concentrations in normal volunteers and patients with Cushing's disease. J Clin Endocrinol Metab. 1996 Aug; 81(8):3068-72. PMID: 8768876.
      Citations: 3     Fields:    Translation:HumansAnimals
    115. Kalogeras KT, Nieman LK, Friedman TC, Doppman JL, Cutler GB, Chrousos GP, Wilder RL, Gold PW, Yanovski JA. Inferior petrosal sinus sampling in healthy subjects reveals a unilateral corticotropin-releasing hormone-induced arginine vasopressin release associated with ipsilateral adrenocorticotropin secretion. J Clin Invest. 1996 May 01; 97(9):2045-50. PMID: 8621793; PMCID: PMC507278.
      Citations: 7     Fields:    Translation:Humans
    116. Mastorakos G, Scopa CD, Kao LC, Vryonidou A, Friedman TC, Kattis D, Phenekos C, Rabin D, Chrousos GP. Presence of immunoreactive corticotropin-releasing hormone in human endometrium. J Clin Endocrinol Metab. 1996 Mar; 81(3):1046-50. PMID: 8772574.
      Citations: 8     Fields:    Translation:HumansAnimals
    117. Friedman TC, Cool DR, Jayasvasti V, Louie D, Loh YP. Processing of pro-opiomelanocortin in GH3 cells: inhibition by prohormone convertase 2 (PC2) antisense mRNA. Mol Cell Endocrinol. 1996 Jan 15; 116(1):89-96. PMID: 8822269.
      Citations: 6     Fields:    Translation:AnimalsCells
    118. Nillni EA, Friedman TC, Todd RB, Birch NP, Loh YP, Jackson IM. Pro-thyrotropin-releasing hormone processing by recombinant PC1. J Neurochem. 1995 Dec; 65(6):2462-72. PMID: 7595540.
      Citations: 19     Fields:    Translation:AnimalsCells
    119. Mastorakos G, Bouzas EA, Silver PB, Sartani G, Friedman TC, Chan CC, Caspi RR, Chrousos GP. Immune corticotropin-releasing hormone is present in the eyes of and promotes experimental autoimmune uveoretinitis in rodents. Endocrinology. 1995 Oct; 136(10):4650-8. PMID: 7664685.
      Citations: 5     Fields:    Translation:Animals
    120. Friedman TC, Loh YP, Cawley NX, Birch NP, Huang SS, Jackson IM, Nillni EA. Processing of prothyrotropin-releasing hormone (Pro-TRH) by bovine intermediate lobe secretory vesicle membrane PC1 and PC2 enzymes. Endocrinology. 1995 Oct; 136(10):4462-72. PMID: 7664666.
      Citations: 14     Fields:    Translation:AnimalsCells
    121. Dorn LD, Burgess ES, Dubbert B, Simpson SE, Friedman T, Kling M, Gold PW, Chrousos GP. Psychopathology in patients with endogenous Cushing's syndrome: 'atypical' or melancholic features. Clin Endocrinol (Oxf). 1995 Oct; 43(4):433-42. PMID: 7586617.
      Citations: 31     Fields:    Translation:Humans
    122. Friedman TC, Yanovski JA. Morning plasma free cortisol: inability to distinguish patients with mild Cushing syndrome from patients with pseudo-Cushing states. J Endocrinol Invest. 1995 Oct; 18(9):696-701. PMID: 8719300.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    123. Friedman TC, Yanovski JA, Jayasvasti V, Yanovski SZ, Koenig RJ, Wilk S. Pyroglutamyl peptidase-II ("thyroliberinase") activity in human serum: influence of weight and thyroid status. J Clin Endocrinol Metab. 1995 Apr; 80(4):1086-9. PMID: 7714073.
      Citations: 2     Fields:    Translation:Humans
    124. Pu LP, Hayes WP, Mill JF, Ghose S, Friedman TC, Loh YP. Frog prohormone convertase PC2 mRNA has a mammalian-like expression pattern in the central nervous system and is colocalized with a subset of thyrotropin-releasing hormone-expressing neurons. J Comp Neurol. 1995 Mar 27; 354(1):71-86. PMID: 7615876.
      Citations: 2     Fields:    Translation:AnimalsCells
    125. Friedman TC, Gordon VM, Leppla SH, Klimpel KR, Birch NP, Loh YP. In vitro processing of anthrax toxin protective antigen by recombinant PC1 (SPC3) and bovine intermediate lobe secretory vesicle membranes. Arch Biochem Biophys. 1995 Jan 10; 316(1):5-13. PMID: 7840657.
      Citations: 2     Fields:    Translation:AnimalsCells
    126. Vgontzas AN, Friedman TC, Chrousos GP, Bixler EO, Vela-Bueno A, Kales A. Delta sleep-inducing peptide in normal humans and in patients with sleep apnea and narcolepsy. Peptides. 1995; 16(6):1153-6. PMID: 8532601.
      Citations:    Fields:    Translation:HumansCells
    127. Loh YP, Cawley NX, Friedman TC, Pu LP. Yeast and mammalian basic residue-specific aspartic proteases in prohormone conversion. Adv Exp Med Biol. 1995; 362:519-27. PMID: 8540366.
      Citations:    Fields:    Translation:HumansAnimalsCells
    128. Friedman TC, García-Borreguero D, Hardwick D, Akuete CN, Doppman JL, Dorn LD, Barker CN, Yanovski JA, Chrousos GP. Decreased delta-sleep and plasma delta-sleep-inducing peptide in patients with Cushing syndrome. Neuroendocrinology. 1994 Dec; 60(6):626-34. PMID: 7700506.
      Citations: 2     Fields:    Translation:Humans
    129. Mastorakos G, Scopa CD, Vryonidou A, Friedman TC, Kattis D, Phenekos C, Merino MJ, Chrousos GP. Presence of immunoreactive corticotropin-releasing hormone in normal and polycystic human ovaries. J Clin Endocrinol Metab. 1994 Oct; 79(4):1191-7. PMID: 7525629.
      Citations: 12     Fields:    Translation:Humans
    130. Friedman TC, Loh YP, Birch NP. In vitro processing of proopiomelanocortin by recombinant PC1 (SPC3). Endocrinology. 1994 Sep; 135(3):854-62. PMID: 8070378.
      Citations: 7     Fields:    Translation:AnimalsCells
    131. Auchus RJ, Mastorakos G, Friedman TC, Chrousos GP. Corticotropin-releasing hormone production by a small cell carcinoma in a patient with ACTH-dependent Cushing's syndrome. J Endocrinol Invest. 1994 Jun; 17(6):447-52. PMID: 7930390.
      Citations: 9     Fields:    Translation:Humans
    132. Friedman TC, Garcia-Borreguero D, Hardwick D, Akuete CN, Stambuk MK, Dorn LD, Starkman MN, Loh YP, Chrousos GP. Diurnal rhythm of plasma delta-sleep-inducing peptide in humans: evidence for positive correlation with body temperature and negative correlation with rapid eye movement and slow wave sleep. J Clin Endocrinol Metab. 1994 May; 78(5):1085-9. PMID: 8175965.
      Citations:    Fields:    Translation:Humans
    133. Friedman TC, Chen HC, Loh YP. Generation of 1-37 and 1-38 forms of adrenocorticotropin by mono- and dipeptidyl serine carboxypeptidase activities in bovine pituitary secretory vesicles. Endocrinology. 1993 Dec; 133(6):2951-61. PMID: 8243323.
      Citations:    Fields:    Translation:Animals
    134. Bouzas EA, Mastorakos G, Friedman TC, Scott MH, Chrousos GP, Kaiser-Kupfer MI. Posterior subcapsular cataract in endogenous Cushing syndrome: an uncommon manifestation. Invest Ophthalmol Vis Sci. 1993 Dec; 34(13):3497-500. PMID: 8258505.
      Citations: 4     Fields:    Translation:Humans
    135. Friedman TC, Chrousos GP. Transsphenoidal resection in Cushing's disease: definition of success. Clin Endocrinol (Oxf). 1993 Dec; 39(6):701. PMID: 8287590.
      Citations:    Fields:    Translation:Humans
    136. Mastorakos G, Webster EL, Friedman TC, Chrousos GP. Immunoreactive corticotropin-releasing hormone and its binding sites in the rat ovary. J Clin Invest. 1993 Aug; 92(2):961-8. PMID: 8394389; PMCID: PMC294936.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    137. Azaryan AV, Wong M, Friedman TC, Cawley NX, Estivariz FE, Chen HC, Loh YP. Purification and characterization of a paired basic residue-specific yeast aspartic protease encoded by the YAP3 gene. Similarity to the mammalian pro-opiomelanocortin-converting enzyme. J Biol Chem. 1993 Jun 05; 268(16):11968-75. PMID: 8389368.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    138. Mixson AJ, Friedman TC, Katz DA, Feuerstein IM, Taubenberger JK, Colandrea JM, Doppman JL, Oldfield EH, Weintraub BD. Thyrotropin-secreting pituitary carcinoma. J Clin Endocrinol Metab. 1993 Feb; 76(2):529-33. PMID: 8432799.
      Citations: 22     Fields:    Translation:Humans
    139. Oerter KE, Friedman TC, Anderson HC, Cassorla FG. Familial syndrome of endocrine and neuroectodermal abnormalities. Am J Med Genet. 1992 Nov 01; 44(4):487-91. PMID: 1442893.
      Citations: 2     Fields:    Translation:Humans
    140. Doppman JL, Gill JR, Miller DL, Chang R, Gupta R, Friedman TC, Choyke PL, Feuerstein IM, Dwyer AJ, Jicha DL, et al. Distinction between hyperaldosteronism due to bilateral hyperplasia and unilateral aldosteronoma: reliability of CT. Radiology. 1992 Sep; 184(3):677-82. PMID: 1509049.
      Citations: 19     Fields:    Translation:Humans
    141. Estivariz FE, Friedman TC, Chikuma T, Loh YP. Processing of adrenocorticotropin by two proteases in bovine intermediate lobe secretory vesicle membranes. A distinct acidic, tetrabasic residue-specific calcium-activated serine protease and a PC2-like enzyme. J Biol Chem. 1992 Apr 15; 267(11):7456-63. PMID: 1313803.
      Citations: 7     Fields:    Translation:AnimalsCells
    142. Friedman TC, Wilk S. Delineation of a particulate thyrotropin-releasing hormone-degrading enzyme in rat brain by the use of specific inhibitors of prolyl endopeptidase and pyroglutamyl peptide hydrolase. J Neurochem. 1986 Apr; 46(4):1231-9. PMID: 2869108.
      Citations: 7     Fields:    Translation:Animals
    143. Friedman TC, Davies TF, Wilk S. Evidence for regulation of a thyrotropin-releasing hormone degradation pathway in GH3 cells. Endocrinology. 1986 Feb; 118(2):562-6. PMID: 3080309.
      Citations: 1     Fields:    Translation:AnimalsCells
    144. Friedman TC, Wilk S. The effect of inhibitors of prolyl endopeptidase and pyroglutamyl peptide hydrolase on TRH degradation in rat serum. Biochem Biophys Res Commun. 1985 Oct 30; 132(2):787-94. PMID: 2865955.
      Citations: 3     Fields:    Translation:Animals
    145. Wilk S, Friedman TC, Kline TB. Pyroglutamyl diazomethyl ketone: potent inhibitor of mammalian pyroglutamyl peptide hydrolase. Biochem Biophys Res Commun. 1985 Jul 31; 130(2):662-8. PMID: 2862865.
      Citations: 2     Fields:    Translation:Animals
    146. Friedman TC, Orlowski M, Wilk S. Peptide-degrading enzymatic activities in GH3 cells and rat anterior pituitary homogenates. Endocrinology. 1984 Apr; 114(4):1407-12. PMID: 6368204.
      Citations: 1     Fields:    Translation:AnimalsCells
    147. Friedman TC, Orlowski M, Wilk S. Prolyl endopeptidase: inhibition in vivo by N-benzyloxycarbonyl-prolyl-prolinal. J Neurochem. 1984 Jan; 42(1):237-41. PMID: 6358414.
      Citations: 4     Fields:    Translation:Animals
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