"Protein Kinase C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
| Descriptor ID |
D011493
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.725
|
| Concept/Terms |
Protein Kinase C- Protein Kinase C
- Calcium-Activated Phospholipid-Dependent Kinase
- Calcium Activated Phospholipid Dependent Kinase
- Phospholipid-Dependent Kinase, Calcium-Activated
- PKC Serine-Threonine Kinase
- PKC Serine Threonine Kinase
- Serine-Threonine Kinase, PKC
- Calcium Phospholipid-Dependent Protein Kinase
- Calcium Phospholipid Dependent Protein Kinase
- Phospholipid-Sensitive Calcium-Dependent Protein Kinase
- Phospholipid Sensitive Calcium Dependent Protein Kinase
|
Below are MeSH descriptors whose meaning is more general than "Protein Kinase C".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C".
This graph shows the total number of publications written about "Protein Kinase C" by people in this website by year, and whether "Protein Kinase C" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2002 | 2 | 1 | 3 |
| 2003 | 1 | 0 | 1 |
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 2 | 2 | 4 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 0 | 2 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Protein Kinase C" by people in Profiles.
-
Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models. Elife. 2022 10 04; 11.
-
Protein kinase D: A therapeutic target in experimental alcoholic pancreatitis. Biochim Biophys Acta Mol Basis Dis. 2022 11 01; 1868(11):166486.
-
Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis. Biochim Biophys Acta Mol Basis Dis. 2021 01 01; 1867(1):165987.
-
Hypoxia and hyperoxia potentiate PAF receptor-mediated effects in newborn ovine pulmonary arterial smooth muscle cells: significance in oxygen therapy of PPHN. Physiol Rep. 2016 Jun; 4(12).
-
Phorbol 12,13 dibutyrate behaves in a tumor-inhibitory manner in esophageal adenocarcinoma cell lines. Dis Esophagus. 2011 Nov; 24(8):611-6.
-
Mechanism for nicotine-induced up-regulation of Wnt signaling in human alveolar interstitial fibroblasts. Exp Lung Res. 2011 Apr; 37(3):144-54.
-
A novel protein kinase D inhibitor attenuates early events of experimental pancreatitis in isolated rat acini. Am J Physiol Gastrointest Liver Physiol. 2011 Jan; 300(1):G120-9.
-
Protein kinase D1 mediates NF-kappaB activation induced by cholecystokinin and cholinergic signaling in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 2008 Dec; 295(6):G1190-201.
-
The novel protein kinase C isoforms -delta and -epsilon modulate caerulein-induced zymogen activation in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 2008 Jun; 294(6):G1344-53.
-
Retinoic acid stimulation of the sodium/iodide symporter in MCF-7 breast cancer cells is mediated by the insulin growth factor-I/phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase signaling pathways. J Clin Endocrinol Metab. 2008 May; 93(5):1884-92.