MAP Kinase Kinase Kinases
"MAP Kinase Kinase Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs).
Descriptor ID |
D020930
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MeSH Number(s) |
D08.811.913.696.620.682.700.559 D12.644.360.400 D12.776.476.400
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Concept/Terms |
MAP Kinase Kinase Kinases- MAP Kinase Kinase Kinases
- Mitogen-Activated Protein Kinase Kinase Kinases
- Mitogen Activated Protein Kinase Kinase Kinases
- Kinases, MAP Kinase Kinase
- MAP3 Kinases
- Kinases, MAP3
- MAP Kinase Kinase Kinase
- MAPKKKs
MAPK-ERK Kinase Kinases- MAPK-ERK Kinase Kinases
- Kinase Kinases, MAPK-ERK
- Kinases, MAPK-ERK Kinase
- MAPK ERK Kinase Kinases
- MEK Kinases
- Kinases, MEK
- MEKKs
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Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase Kinases".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase Kinases".
This graph shows the total number of publications written about "MAP Kinase Kinase Kinases" by people in this website by year, and whether "MAP Kinase Kinase Kinases" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2013 | 1 | 0 | 1 |
2014 | 2 | 0 | 2 |
2017 | 0 | 2 | 2 |
2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "MAP Kinase Kinase Kinases" by people in Profiles.
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MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment. Cell Death Dis. 2019 02 11; 10(2):120.
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The contribution of toll-like receptor signaling to the development of liver fibrosis and cancer in hepatocyte-specific TAK1-deleted mice. Int J Cancer. 2018 01 01; 142(1):81-91.
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Modulation of transforming growth factor-ß/follistatin signaling and white adipose browning: therapeutic implications for obesity related disorders. Horm Mol Biol Clin Investig. 2017 Sep 09; 31(2).
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TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78.
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TAK1 regulates hepatic cell survival and carcinogenesis. J Gastroenterol. 2014 Feb; 49(2):185-94.
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Transforming growth factor-? signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1. Gastroenterology. 2013 May; 144(5):1042-1054.e4.