"Cyclins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large family of regulatory proteins that function as accessory subunits to a variety of CYCLIN-DEPENDENT KINASES. They generally function as ENZYME ACTIVATORS that drive the CELL CYCLE through transitions between phases. A subset of cyclins may also function as transcriptional regulators.
Descriptor ID |
D016213
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MeSH Number(s) |
D12.644.360.262 D12.776.167.218 D12.776.476.262
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cyclins".
Below are MeSH descriptors whose meaning is more specific than "Cyclins".
This graph shows the total number of publications written about "Cyclins" by people in this website by year, and whether "Cyclins" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1998 | 0 | 1 | 1 |
1999 | 0 | 1 | 1 |
2001 | 0 | 1 | 1 |
2007 | 0 | 1 | 1 |
2009 | 1 | 0 | 1 |
2014 | 0 | 1 | 1 |
2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cyclins" by people in Profiles.
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Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models. Elife. 2022 10 04; 11.
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The regulatory function of miR-200c on inflammatory and cell-cycle associated genes in SK-LMS-1, a leiomyosarcoma cell line. Reprod Sci. 2015 May; 22(5):563-71.
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Positive transcription elongation factor b activity in compensatory myocardial hypertrophy is regulated by cardiac lineage protein-1. Circ Res. 2009 Jun 19; 104(12):1347-54.
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Pivotal role of cardiac lineage protein-1 (CLP-1) in transcriptional elongation factor P-TEFb complex formation in cardiac hypertrophy. Cardiovasc Res. 2007 Jul 01; 75(1):129-38.
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Activation of caspase-3 activity and apoptosis in MDA-MB-468 cells by N(omega)-hydroxy-L-arginine, an inhibitor of arginase, is not solely dependent on reduction in intracellular polyamines. Carcinogenesis. 2001 Nov; 22(11):1863-9.
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Monoclonal antibody to HER-2/neureceptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene. Cancer Res. 1999 Mar 15; 59(6):1347-55.
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Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs. Oncogene. 1998 Oct 29; 17(17):2235-49.