"Somatostatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.
Descriptor ID |
D013004
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MeSH Number(s) |
D06.472.699.327.700.875 D06.472.699.587.780 D12.644.400.400.700.875 D12.644.548.365.700.875 D12.644.548.586.780 D12.776.631.650.405.700.875
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Concept/Terms |
Somatostatin- Somatostatin
- SRIH-14
- Somatotropin Release-Inhibiting Factor
- Somatotropin Release Inhibiting Factor
- Cyclic Somatostatin
- Somatostatin-14
- Somatostatin 14
- Somatotropin Release-Inhibiting Hormone
- Somatotropin Release Inhibiting Hormone
- Somatostatin, Cyclic
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Below are MeSH descriptors whose meaning is more general than "Somatostatin".
Below are MeSH descriptors whose meaning is more specific than "Somatostatin".
This graph shows the total number of publications written about "Somatostatin" by people in this website by year, and whether "Somatostatin" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 1 | 1 |
2000 | 1 | 0 | 1 |
2008 | 1 | 0 | 1 |
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Below are the most recent publications written about "Somatostatin" by people in Profiles.
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Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat. Nat Neurosci. 2008 May; 11(5):538-40.
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Blockade of mu-opioid receptors reveals the hyperalgesic effect of orphanin FQ/nociceptin in the rat hot plate test. Br J Pharmacol. 2000 Dec; 131(8):1684-8.
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Yeast and mammalian basic residue-specific aspartic proteases in prohormone conversion. Adv Exp Med Biol. 1995; 362:519-27.
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Alpha-melanocyte stimulating hormone discloses a stimulatory effect of beta-endorphin on somatostatin release. Brain Res. 1987 Aug 04; 417(1):127-30.
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The development of prolactin, growth hormone, alpha-melanocyte-stimulating hormone and monoaminergic systems in the rat. Monogr Neural Sci. 1986; 12:1-6.
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Insulin secretion and action in the hyperthyroid rat. Horm Metab Res. 1985 Aug; 17(8):383-6.
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Partial characterization of immunoreactive substance P in the rat pituitary gland. Life Sci. 1984 Jan 16; 34(3):225-38.
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Recent studies on the role of brain peptides in control of anterior pituitary hormone secretion. Peptides. 1984; 5 Suppl 1:3-7.
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Pre- and postnatal developmental changes in hypothalamic and pituitary content of alpha-melanocyte-stimulating hormone and somatostatin in the rat. Biol Neonate. 1984; 46(2):80-8.
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Development of hypothalamic control of growth hormone secretion in the rat. Endocrinology. 1983 Aug; 113(2):720-8.