"Naltrexone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
| Descriptor ID |
D009271
|
| MeSH Number(s) |
D03.132.577.249.706.550 D03.605.497.750.550 D03.633.400.686.750.550 D04.615.723.795.706.550
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Naltrexone".
Below are MeSH descriptors whose meaning is more specific than "Naltrexone".
This graph shows the total number of publications written about "Naltrexone" by people in this website by year, and whether "Naltrexone" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 1 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Naltrexone" by people in Profiles.
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Anti-nociception mediated by a ? opioid receptor agonist is blocked by a d receptor agonist. Br J Pharmacol. 2015 Jan; 172(2):691-703.
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Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2. Peptides. 2013 Sep; 47:99-109.
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The rewarding action of acute cocaine is reduced in ß-endorphin deficient but not in µ opioid receptor knockout mice. Eur J Pharmacol. 2012 Jul 05; 686(1-3):50-4.
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The role of endogenous dynorphin in ethanol-induced state-dependent CPP. Behav Brain Res. 2012 Feb 01; 227(1):58-63.
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Blockade of mu-opioid receptors reveals the hyperalgesic effect of orphanin FQ/nociceptin in the rat hot plate test. Br J Pharmacol. 2000 Dec; 131(8):1684-8.
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Mechanical activation of dorsal root ganglion cells in vitro: comparison with capsaicin and modulation by kappa-opioids. Brain Res. 2000 Feb 21; 856(1-2):101-10.
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Effect of adrenal and sex hormones on opioid analgesia and opioid receptor regulation. Pharmacol Biochem Behav. 1992 Aug; 42(4):685-92.
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Dissociation of opioid receptor upregulation and functional supersensitivity. Pharmacol Biochem Behav. 1991 Apr; 38(4):853-9.
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The role of opioid receptor density in morphine tolerance. J Pharmacol Exp Ther. 1991 Feb; 256(2):575-80.
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Simultaneous development of opioid tolerance and opioid antagonist-induced receptor upregulation. Brain Res. 1990 Oct 08; 529(1-2):143-8.