"Mice, Knockout" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Descriptor ID |
D018345
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MeSH Number(s) |
B01.050.050.136.500.500 B01.050.150.900.649.313.992.635.505.500.550.455 B01.050.150.900.649.313.992.635.505.500.800.500
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Concept/Terms |
Mice, Knockout- Mice, Knockout
- Mice, Knock-out
- Knock-out Mice
- Mice, Knock out
- Mouse, Knockout
- Knockout Mouse
- Knockout Mice
|
Below are MeSH descriptors whose meaning is more general than "Mice, Knockout".
Below are MeSH descriptors whose meaning is more specific than "Mice, Knockout".
This graph shows the total number of publications written about "Mice, Knockout" by people in this website by year, and whether "Mice, Knockout" was a major or minor topic of these publications.
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click here.
Year | Major Topic | Minor Topic | Total |
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1997 | 0 | 1 | 1 |
1999 | 0 | 1 | 1 |
2000 | 0 | 2 | 2 |
2001 | 0 | 4 | 4 |
2003 | 0 | 4 | 4 |
2004 | 0 | 4 | 4 |
2005 | 0 | 3 | 3 |
2006 | 0 | 2 | 2 |
2007 | 0 | 4 | 4 |
2008 | 0 | 2 | 2 |
2009 | 0 | 4 | 4 |
2010 | 0 | 7 | 7 |
2011 | 0 | 6 | 6 |
2012 | 0 | 4 | 4 |
2013 | 0 | 6 | 6 |
2014 | 0 | 6 | 6 |
2015 | 0 | 2 | 2 |
2016 | 0 | 5 | 5 |
2017 | 0 | 2 | 2 |
2018 | 0 | 3 | 3 |
2019 | 0 | 5 | 5 |
2020 | 0 | 5 | 5 |
2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "Mice, Knockout" by people in Profiles.
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Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts. J Clin Invest. 2021 06 01; 131(11).
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Epithelial membrane protein 2 (Emp2) modulates innate immune cell population recruitment at the maternal-fetal interface. J Reprod Immunol. 2021 06; 145:103309.
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A RAC-GEF network critical for early intestinal tumourigenesis. Nat Commun. 2021 01 04; 12(1):56.
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Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22. Proc Natl Acad Sci U S A. 2021 01 05; 118(1).
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Local M-CSF (Macrophage Colony-Stimulating Factor) Expression Regulates Macrophage Proliferation and Apoptosis in Atherosclerosis. Arterioscler Thromb Vasc Biol. 2021 01; 41(1):220-233.
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Reciprocal Regulation Between Forkhead Box M1/NF-?B and Methionine Adenosyltransferase 1A Drives Liver Cancer. Hepatology. 2020 11; 72(5):1682-1700.
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The role of pituitary adenylyl cyclase activating polypeptide in affective signs of nicotine withdrawal. J Neurosci Res. 2020 08; 98(8):1549-1560.
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Epithelial Membrane Protein 2 (EMP2) Promotes VEGF-Induced Pathological Neovascularization in Murine Oxygen-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2020 02 07; 61(2):3.
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Lack of adipose-specific hexose-6-phosphate dehydrogenase causes inactivation of adipose glucocorticoids and improves metabolic phenotype in mice. Clin Sci (Lond). 2019 11 15; 133(21):2189-2202.
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A mouse model for chronic intermittent electronic cigarette exposure exhibits nicotine pharmacokinetics resembling human vapers. J Neurosci Methods. 2019 10 01; 326:108376.